We are concluding two years of DFID and Wellcome Trust-funded disaster mental health intervention research in Nepal, having worked with over 700 persons in five earthquake and flood affected communities throughout the country. We describe this innovative mental health integrated disaster preparedness intervention, share research results, and consider lessons learned. Preliminary data outcomes indicate that the 3-day community intervention increased disaster preparedness behaviors and preparedness self-efficacy, decreased symptoms of depression and post-traumatic stress, and increased mental health related help-giving and help-seeking. In addition to quantitative data based on a randomized controlled trial and cluster comparisons, we share qualitative feedback from focus groups emphasizing firsthand accounts from local community members about the impact of natural disasters on well-being and reactions to the intervention. We hope to encourage discussion about how to build resilience among at risk communities, and about how partnerships between universities and local organizations, such as Transcultural Psychosocial Organization, Nepal, can be useful frameworks for conducting applied research with immediate benefits to disaster affected communities.